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Laparoscopy and hysteroscopy are minimally invasive, out-patient surgeries that can provide a diagnosis and sometimes even offer improved pregnancy rates if scar tissue or endometriosis is found and treated at the time of surgery. The final, most aggressive form of treatment for unexplained infertility is in vitro fertilization. This treatment is discussed in great detail in other sections of this web site. Although it is the most aggressive form of therapy for unexplained infertility, it is also the most successful form of therapy. The major advantage of in vitro fertilization over gonadotropin therapy combined with IUI, in addition to a significantly higher pregnancy rate, is a significant reduction in the risk of high order multiple pregnancy. In summary, unexplained infertility is a relatively common cause of infertility. This diagnosis is only made after a complete basic evaluation for infertility has failed to reveal a definitive cause for the couple’s infertility. Despite the lack of a definitive diagnosis, several effective treatments are available for unexplained infertility, resulting in respectable pregnancy rates with a minimum risk of adverse effects.
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